杰夫·坎农教授有机化学，并从事有机合成和催化方面的研究.
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预约办公时间
Research Interests
所有有机分子的核心都是由碳碳键组成的. 我们小组对开发新的建造方法很感兴趣. To accomplish this, 我们分析有趣和复杂的目标，设计创造性和高效的方法来合成它们. 我们特别感兴趣的是能够催化和立体选择性地完成这一过程的方法. 我们的研究通过使用计算方法来帮助预测和解释实验结果.
Courses
有机化学I和II(化学220和221)
有机化学入门课程旨在让学生了解含碳共价键分子的结构和相互作用. 关键主题包括结构和分子间相互作用，反应性和合成. 特别强调的是围绕多步骤合成和反应机制中的电子运动发展逻辑解决问题的能力.
有机化学实验室I和II(化学220L和221L)
有机化学实验室讲授有机化学的技术和一般反应. 第一学期的重点是介绍适当的技术进行反应, purifying products, 并分析了这些产品的结构和纯度. 第二学期将运用这些技术合成几种有趣的有机分子.
物理有机化学(化学360)
物理有机化学是对有机反应及其机理的详细研究. In this class, 学生被赋予工具来创建有机过程的机械假设和设计实验来支持或反驳他们. 学生将能够运用前沿分子轨道理论来概括反应性. 学生还将接触密度泛函理论(DFT)作为研究有机反应的结构和反应性的方法.
在奇数年的春天提供
Publications
Katherine C. 福布斯*，安妮·玛丽·克鲁克*，尤里·李*，川田正武*，Kian M. Shamskhou*, Rachel A. Zhang*, Jeffrey S. Cannon; "Photoredox-catalyzed Oxidation of Anions for the Atom-Economical Hydro-, Amido-, 和烯烃的对话," J. Org. Chem. 2022, 87, 3498–3510. doi: 10.1021/acs.joc.1c03055
Donald R. Deardorff, Scott W. Niman*, Mark I. Paulsen*， Anasheh Sookezian*， Meghan E. 克里斯托弗·J·惠伦*. FInlayson*， Collrane Frivold*， Hilary C. Brown*, Jeffrey S. Cannon; "Development of a Combined Enzyle- and Transition Metal-Catalyzed Strategy for the SYnthesis of Heterocycles: Enentioselective Syntheses of (–)-Coniine, DAB-1, and Nectrisine," ACS Omega 2020, 5, 2005–2014. doi: 10.1021/acsomega.9b03990
Jeffrey S. Cannon, Larry E. Overman; "Discussion Addendum for Preparation of the COP Catalysts: [(S)-COP-OAc]2, [(S)-COP-Cl]2, and (S)-COP-hfacac," Org. Synth. 2018, 95, 500-511. doi: 10.15227/orgsyn.095.0500
Natalie C. Dwulet*, Tina A. Zolfaghari*, Molly L. Brown*, Jeffrey S. Cannon; "Diastereoselective Synthesis of Unnatural Amino Acids by alkylation of α-tert-丁砜酰胺辅助结合烯醇酸酯 J. Org. Chem. 2018, 83, 11510-11518. doi: 10.1021/acs.joc.8b01379
Nicholas J. Foy*, Katherine C. 福布斯*，安妮·玛丽·克鲁克*，麦克斯韦尔·D. Gruber*, Jeffrey S. Cannon; "Dual Lewis Acid/Photoredox-Catalyzed Addition of Ketyl Radicals to Vinylogous Carbonates in the Synthesis of 2,6-Dioxabicyclo[3.3.0]octan-3-ones," Org. Lett. 2018, 20, 5727-5731. doi: 10.1021/acs.orglett.8b02442
Jeffrey S. Cannon; "A Nitrone Dipolar Cycloaddition Strategy toward an Enantioselective Synthesis of Massadine," Org. Lett. 2018, 20, 3883-3887, doi: 10.1021/acs.orglett.8b01464
罗绍雄，Jeffrey S. Cannon, Buck L. H. Taylor, Keary M. Engle, K. N. Houk, Robert H. Grubbs; "Z- 3的选择性交叉复合和同二聚化E1,3-二烯:反应优化、计算分析和合成应用” J. Am. Chem. Soc. 2016, 14039-14046, doi: 10.1021/jacs.6b08387
Jeffrey S. Cannon, Larry E. Overman; "Palladium(II)-Catalyzed Enantioselective Reactions Using COP Catalysts," Acc. Chem. Res. 2016, 2220-2231. doi: 10.1021/acs.accounts.6b00398
Jeffrey S. 邹陆峰，刘鹏，兰宇，J. O'Leary, K. N. Houk, Robert H. Grubbs; "Carboxylate-Assisted C(sp3烯烃合成相关钌配合物中的h活化." J. Am. Chem. Soc. 2014, 136, 6733-6743. doi: 10.1021/ja5021958
Jeffrey S. Cannon, Robert H. Grubbs; “Alkene Chemoselectivity in Ruthenium-Catalyzed Z‑Selective Olefin Metathesis,” Angew. Chem., Int. Ed. 2013, 52, 9001–9004. doi: 10.1002/anie.201302724
Jeffrey S. Cannon, Angela C. Olson, Larry E. Overman; “Palladium(II)-Catalyzed Enantioselective Synthesis of 2-Vinyl Oxygen Heterocycles,” J. Org. Chem. 2012, 77, 1961–1973. doi: 10.1021/jo202553a
Jeffrey S. Cannon, James H. Frederich, Larry E. Overman; “Palladacyclic Imidazoline-Naphthalene Complexes: Synthesis and Catalytic Performance in Pd(II)-Catalyzed Enantioselective Reactions of Allylic Trichloroacetimidates,” J. Org. Chem. 2012, 77, 1939–1951. doi: 10.1021/jo2025724
Jeffrey S. Cannon, Larry E. Overman; “Is There No End to the Total Syntheses of Strychnine? 《正规博彩十大网站排名推荐》 Angew. Chem., Int. Ed. 2012, 51, 4288–4311. doi: 10.1002/anie.201107385
Jeffrey S. Cannon, Stefan F. Kirsch, Larry E. Overman; “Catalytic Asymmetric Synthesis of Chiral Allylic Esters,” J. Am. Chem. Soc. 2010, 132, 15185–15191. doi: 10.1021/ja106685w
Jeffrey S. Cannon, Stefan F. Kirsch, Larry E. Overman, Helen F. Sneddon; “Mechanism of the Cobalt Oxazoline Palladacycle (COP)-Catalyzed Asymmetric Synthesis of Allylic Esters,” J. Am. Chem. Soc. 2010, 132, 15192–15203. doi: 10.1021/ja106688j